Association between perihematomal perfusion and intracerebral hemorrhage shape

• DOI: 10.1007/s00234-021-02709-8
• Publication Date: 2021-04-15T06:33:11Z
• Authors: Andrea Morotti; Giorgio Busto; Elisa Scola; Edoardo Carlesi; Francesca Di Pasq...; Ilaria Casetta; Enrico Fainardi
• Keywords: Cerebral blood flow; CT perfusion; Intracerebral hemorrhage; Irregular shape; Cerebral Hemorrhage; Cerebrovascular Circulation; Humans; Perfusion; Tomography, X-Ray Computed; Brain Edema; Hematoma; Perfusion; Cerebral blood flow; CT perfusion; Intracerebral hemorrhage; Irregular shape; Hematoma; 03 medical and health sciences; 0302 clinical medicine; Cerebrovascular Circulation; Humans; Brain Edema; Tomography, X-Ray Computed; Cerebral Hemorrhage

The pathophysiological determinants of irregular intracerebral hemorrhage (ICH) shape are unclear. We aimed at characterizing the relationship between perihematomal perfusion and ICH shape.A single-center cohort of patients with primary ICH was analyzed. Patients underwent computed tomography perfusion within 6 h from onset. Cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) were calculated in the manually outlined perihematomal low-density region. ICH shape was rated on baseline non-contrast CT following international consensus criteria, and predictors of irregular shape were explored with logistic regression.A total of 150 patients were included, of whom 66 (44%) had irregular shape. Perihematomal CBF was lower in irregular ICH (median 23 vs 35 mL/100 g/min, p<0.001). CBF<20 mL/100 g/min was independently associated with irregular shape (odds ratio 9.67, 95% CI 2.42-38.69, p=0.001).Our findings suggest that perihematomal hypoperfusion may contribute to the CT appearance of acute ICH.