Sequential MRI in a case of Creutzfeldt-Jakob disease

• DOI: 10.1007/s002340100695
• Publication Date: 2003-02-12T18:38:53Z
• Authors: G. Tribl; G. Strasser; J. Zeitlhofer; S. Asenbaum; C. Jarius; P. Wessely; D. Prayer
• Keywords: Neuroradiology; Creutzfeldt-Jakob Syndrome

A 48-year-old man suddenly developed clinically and electroencephalographically nonspecific dementia. On MRI sequences, only diffusion-weighted images (DWI) of the cortex were unequivocally pathological. Obvious atrophy and basal ganglia signal changes appeared only 9 months after the onset. Brain biopsy confirmed Creutzfeldt-Jakob disease (CJD). In rapidly progressive dementia, we recommend DWI for early diagnosis of CJD.