The Effects of Stabilizing and Directional Selection on Phenotypic and Genotypic Variation in a Population of RNA Enzymes
0301 basic medicine
570
Genotype
Molecular Sequence Data
directional selection
Azoarcus
ribozymes
576
Evolution, Molecular
10127 Institute of Evolutionary Biology and Environmental Studies
03 medical and health sciences
1311 Genetics
1312 Molecular Biology
RNA, Catalytic
experimental evolution
Selection, Genetic
Biology
0303 health sciences
Base Sequence
Genetic Variation
genotype to phenotype
1105 Ecology, Evolution, Behavior and Systematics
Phenotype
stabilizing selection
sequence space
13. Climate action
570 Life sciences; biology
590 Animals (Zoology)
Nucleic Acid Conformation
DOI:
10.1007/s00239-013-9604-x
Publication Date:
2013-12-05T06:43:28Z
AUTHORS (5)
ABSTRACT
The distribution of variation in a quantitative trait and its underlying distribution of genotypic diversity can both be shaped by stabilizing and directional selection. Understanding either distribution is important, because it determines a population's response to natural selection. Unfortunately, existing theory makes conflicting predictions about how selection shapes these distributions, and very little pertinent experimental evidence exists. Here we study a simple genetic system, an evolving RNA enzyme (ribozyme) in which a combination of high throughput genotyping and measurement of a biochemical phenotype allow us to address this question. We show that directional selection, compared to stabilizing selection, increases the genotypic diversity of an evolving ribozyme population. In contrast, it leaves the variance in the phenotypic trait unchanged.
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CITATIONS (11)
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