Atrial Septal Defect: Larger Right Ventricular Dimensions and Atrial Volumes as Early as in the First Month After Birth—a Case–Control Study Including 716 Neonates

• DOI: 10.1007/s00246-023-03211-z
• Publication Date: 2023-06-27T16:02:42Z
• Authors: Anna Maria Dehn; Sofie Dannesbo; Anna Sellmer; Line Høffner; Elisabeth Blixenk...; Anne-Sophie Sillesen; Anna Axelsson Raja; Niels Vejlstrup; Kasper Iversen; Henning Bundgaard; Vibeke Hjortdal
• Keywords: Septum secundum; Ventricular outflow tract

Atrial septal defect (ASD) is characterized by a left-to-right shunt causing dilatation of the right atrium and ventricle as well pulmonary hyperperfusion. The detection ASDs often occurs late in childhood or adulthood. Little known about cardiac structure function neonates with ASD.We analyzed neonatal echocardiograms from Copenhagen Baby Heart Study, multicenter, population-based cohort study 27,595 neonates. We included 716 secundum-type matched them 1:1 on sex age at examination without ASD same birth cohort. Neonates an (median 11 days, 52% female) had larger ventricular (RV) dimensions than controls (RV longitudinal dimension end-diastole: 27.7 mm vs. 26.7 mm, p < 0.001; RV basal 14.9 13.8 outflow tract diameter 13.6 12.4 0.001). volumes were compared to (right atrial end-systolic volume: 2.9 ml 2.1 ml, left volume 2.0 1.8 Tricuspid annular plane systolic excursion was (10.2 9.6 Left did not differ between controls. In conclusion, associated altered already period, echocardiography within first 30 days after birth.ClinicalTrials.gov Identifier: NCT02753348 (April 27, 2016).