Diagnostic magnetic resonance imaging characteristics of congenital mesoblastic nephroma: a retrospective multi-center International Society of Pediatric Oncology-Renal Tumor Study Group (SIOP-RTSG) radiology panel study

• DOI: 10.1007/s00247-024-05918-4
• Publication Date: 2024-04-13T03:42:37Z
• Authors: Justine N. van de...; Jens-Peter Schenk; Carlo Morosi; Tom A. Watson; Ana Coma; Norbert Graf; Tanzina Chowdhury; Gema L. Ramírez-V...; Filippo Spreafico; Nils Welter; Kristina Dzhuma; Harm van Tinteren; Ronald R. de Krijger; Marry M. van den ...; Annemieke S. Litt...
• Keywords: Neuroradiology; Single Center

Abstract Background Congenital mesoblastic nephroma is the most common solid renal tumor in neonates. Therefore, patients <3 months of age are advised to undergo upfront nephrectomy, whereas invasive procedures at diagnosis ≥3 discouraged by International Society Pediatric Oncology-Renal Tumor Study Group (SIOP-RTSG). Nevertheless, discriminating congenital nephroma, especially from more Wilms tumor, solely based on imaging remains difficult. Recently, magnetic resonance (MRI) has become preferred modality. Studies focusing MRI characteristics limited. Objective This study aims identify diagnostic largest series date. Materials and methods In this retrospective multicenter study, five SIOP-RTSG national review radiologists identified 52 MRIs histologically proven nephromas. was performed following protocols, while assessed their cases using a validated case report form. Results Patients (24/52 classic, 11/52 cellular, 15/52 mixed type 2/52 unknown) had median 1 month (range day–3 months). Classic appeared homogeneous with lack hemorrhage, necrosis and/or cysts, showing concentric ring sign 14 (58.3%) patients. Cellular heterogeneous were larger (311.6 174.2 cm 3 , respectively, versus 41.0 for classic ( P <0.001)). All predominantly T2-weighted isointense T1-weighted hypointense, mean overall apparent diffusion coefficient values ranged 1.05–1.10×10 −3 mm 2 /s. Conclusion international collaborative showed presented as mass typical sign, cellular heterogeneous. Future studies may use characteristic validation exploring discriminative non-invasive value MRI, tumor. Graphical