The minor chicken class I gene BF1 is deleted between short imperfect direct repeats in the B14 and typical B15 major histocompatibility complex (MHC) haplotypes

• DOI: 10.1007/s00251-023-01313-9
• Publication Date: 2023-07-05T10:04:36Z
• Authors: Nicolas I. E. Rocos; Felicity J. Coulter; Thomas C. J. Tan; Jim Kaufman
• Keywords: Direct repeat

The chicken major histocompatibility complex (MHC, also known as the BF-BL region of B locus) is notably small and simple with few genes, most which are involved in antigen processing presentation. There two classical class I only BF2 well systemically expressed ligand for cytotoxic T lymphocytes (CTLs). other gene, BF1, believed to be primarily a natural killer (NK) cell ligand. Among standard MHC haplotypes examined detail, BF1 tenfold less than at RNA level due defects promoter or splice site. However, B14 typical B15 haplotypes, was not detected, here, we show that deletion between imperfect 32 nucleotide direct repeats has removed gene entirely. phenotypic effects having (particularly on resistance infectious pathogens) have been systematically explored, but such deletions short found some promoters 5' untranslated (5'UTR) BG genes locus. Despite opposite transcriptional orientation homologous MHC, might prevent loss key from minimal essential it appears can still lead deletion.