The microbial biosynthesis of noncanonical terpenoids

• DOI: 10.1007/s00253-024-13048-y
• Publication Date: 2024-02-21T13:02:38Z
• Authors: Mengyu Ma; Mingkai Li; Zhenke Wu; Xiqin Liang; Qiusheng Zheng; Defang Li; Guoli Wang; Tianyue An
• Keywords: Terpene; Squalene

Abstract Terpenoids are a class of structurally complex, naturally occurring compounds found predominantly in plant, animal, and microorganism secondary metabolites. Classical terpenoids typically have carbon atoms multiples five follow well-defined skeletons, whereas noncanonical deviate from these patterns. These often result the methyltransferase-catalyzed methylation modification substrate units, leading to irregular skeletons. In this comprehensive review, various activities applications terpenes been summarized. Importantly, review delves into biosynthetic pathways terpenes, including those with C6, C7, C11, C12, C16 bacteria fungi host. It also covers triterpenes synthesized non-squalene substrates nortriterpenes Ganoderma lucidum , providing detailed examples elucidate intricate processes involved. Finally, outlines potential future terpenoids. conclusion, insights gathered provide reference for understanding biosynthesis pave way discovery additional unique novel terpenes. Key points • The introduced . skeletons presented microbial is summarized