The agreement of the OMERACT grey-scale ultrasound scoring system for salivary glands and minor salivary gland biopsy results in a single-center cohort of patients with suspected Sjögren’s disease

• DOI: 10.1007/s00256-025-04885-7
• Publication Date: 2025-02-10T17:04:41Z
• Authors: Nanna Surlemont S...; Viktoria Fana; Stylianos Georgiadis; Uffe Møller Døhn; Lene Terslev

Abstract Objective Salivary gland ultrasound (SGUS) is a non-invasive tool for the evaluation of parenchymal changes related to primary Sjögrens disease (pSjD) with potential reduce need minor salivary biopsies when diagnosing patients pSjD. The aim was assess agreement between SGUS findings and biopsy results in suspected Methods All referred suspicion pSjD scheduled diagnostic were included period 2017–2021. underwent parotid submandibular glands bilaterally, Schirmer’s test, unstimulated flow, blood samples including autoantibody analysis. Changes four scored 0–3 using previously developed atlas based on OMERACT scoring system at same pathology department focus score > 1 indicative Results Of 103 included, 43 (42%) diagnosed 40 (39%) fulfilled 2016 ACR/EULAR classification criteria. Thirty-two (31%) had positive biopsy. sensitivity ≥ 2 least 0.59 specificity 0.75. predictive negative values 0.51 0.80, respectively. slightly improved combined an abnormal flow rate or test. Conclusion In pSjD, we found good biopsy; however, cannot yet fully replace setup SjD.