Thoracic aorta calcification but not inflammation is associated with increased cardiovascular disease risk: results of the CAMONA study

• DOI: 10.1007/s00259-016-3552-9
• Publication Date: 2016-10-29T17:43:10Z
• Authors: Björn A. Blomberg; Pim A. de Jong; Anders Thomassen; Marnix G. E. Lam; Werner Vach; Michael H. Olsen; Willem P. T. M. Mali; Jagat Narula; Abass Alavi; Poul F. Høilund-C...
• Keywords: Quartile; Thoracic aorta

Arterial inflammation and vascular calcification are regarded as early prognostic markers of cardiovascular disease (CVD). In this study we investigated the relationship between CVD risk arterial (18F-FDG PET/CT imaging), metabolism (Na18F calcium burden (CT imaging) thoracic aorta in a population at low risk. Study participants underwent blood pressure measurements, analyses, 18F-FDG Na18F imaging. addition, 10-year for development CVD, based on Framingham score (FRS), was estimated. compared across quartiles uptake, CT. A total 139 subjects (52 % men, mean age 49 years, range 21 – 75 median FRS 6 %) were evaluated. was, average, 3.7 times higher among with uptake highest quartile those lowest distribution (15.5 vs. 4.2 %; P < 0.001). CT two (18.0 4.9 similar all uptake. Our findings indicate that an unfavourable profile is associated marked increases aorta, but not inflammation.