PISCOM: a new procedure for epilepsy combining ictal SPECT and interictal PET

• DOI: 10.1007/s00259-018-4080-6
• Publication Date: 2018-08-01T05:44:12Z
• Authors: Andrés Perissinotti; Aida Niñerola-Baizán; Sebastià Rubí; Mar Carreño; Berta Marti-Fuster; Javier Aparicio; Maria Mayoral; Antonio Donaire; Nuria Sanchez-Izq...; Nuria Bargalló; Jordi Rumiá; Teresa Boget; Francesca Pons; Francisco Lomeña; Domènec Ros; Javier Pavía; Xavier Setoain
• Keywords: Statistical parametric mapping; Subtraction

We present a modified version of the SISCOM procedure that uses interictal PET instead SPECT for seizure onset zone localization. called this new nuclear imaging processing technique PISCOM (PET subtracted ictal coregistered with MRI).We retrospectively studied 23 patients (age range 4-61 years) medically refractory epilepsy who had undergone MRI, SPECT, and FDG been seizure-free at least 2 years after surgical treatment. images were reprocessed (rFDG PET) to assimilate features image subtraction. Interictal rFDG compared using statistical parametric mapping (SPM). evaluated visually an automated volume interest-based analysis. The results two studies each other known resection site.SPM showed no significant differences in cortical activity between images. equivalent 17 (74%). was successfully identified 19 (83%) by (74%) SISCOM: 15 (65%) techniques concordant successful results. analysis identifying extension zone. However, lower amount indeterminate due propagation, background or artefacts.Preliminary findings initial proof-of-concept study suggest perfusion glucose metabolism cerebral cortex can be correlated may valid identification further are needed validate these