Early-phase [18F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury

• DOI: 10.1007/s00259-020-04788-w
• Publication Date: 2020-04-21T05:03:13Z
• Authors: Leonie Beyer; Alexander Nitschmann; Henryk Barthel; Thilo van Eimeren; Marcus Unterrainer; Julia Sauerbeck; Ken Marek; Mengmeng Song; Carla Palleis; Gesine Respondek; Jochen Hammes; Michael T. Barbe; Özgür Onur; Frank Jessen; Dorothee Saur; Matthias L. Schro...; Jost-Julian Rumpf; Michael Rullmann; Andreas Schildan; Marianne Patt; Bernd Neumaier; Olivier Barret; Jennifer Madonia; David S. Russell; Andrew W. Stephens; Sigrun Roeber; Jochen Herms; Kai Bötzel; Johannes Levin; Joseph Classen; Günter U. Höglinger; Peter Bartenstein; Victor Villemagne; Alexander Drzezga; John Seibyl; Osama Sabri; Matthias Brendel
• Keywords: Standardized uptake value; Corticobasal degeneration; Fluorodeoxyglucose; Neuroradiology

Abstract Purpose Second-generation tau radiotracers for use with positron emission tomography (PET) have been developed visualization of deposits in vivo. For several β-amyloid and first-generation tau-PET radiotracers, it has shown that early-phase images can be used as a surrogate neuronal injury. Therefore, we investigated the performance early acquisitions novel radiotracer [ 18 F]PI-2620 potential substitute F]fluorodeoxyglucose ([ F]FDG). Methods Twenty-six subjects were referred suspected tauopathies or overlapping parkinsonian syndromes (Alzheimer’s disease, progressive supranuclear palsy, corticobasal syndrome, multi-system atrophy, Parkinson’s Parkinson's frontotemporal dementia) received dynamic (0–60 min p.i.) static F]FDG-PET (30–50 p.i.). Regional standardized uptake value ratios (single frame SUVr) blood flow estimate (R 1 ) F]PI-2620-PET correlated corresponding quantification (global mean/cerebellar normalization). Reduced tracer cortical target regions was also interpreted visually using 3-dimensional stereotactic surface projections by three more less experienced readers. Spearman rank correlation coefficients calculated between all frequencies disagreement compared both Results Highest agreement reached acquisition from 0.5 to 2.5 p.i. global mean (lowest R = 0.69) cerebellar scaling 0.63). Correlation (summed 0.5–2.5 SUVr & displayed strong 0.76, R1 0.77) normalization 0.68, 0.68). Visual interpretation revealed high regional correlations F]FDG-PET. There no relevant differences Conclusion Early-phase imaging serve biomarker Dynamic dual time-point protocol could supersede additional indexing distribution extent