[18F]SiTATE-PET/CT for detection of pheochromocytomas and paragangliomas: comparison of biochemical secretion, genotype and imaging metrics

• DOI: 10.1007/s00259-025-07341-9
• Publication Date: 2025-05-30T03:45:16Z
• Authors: Meike Onkes; Paul Dahlmann; Alena Gesenhues; Sean Ira G. Gacula; Nabeel Mansour; Júnia R. O. L. Sc...; Isabel Stüfchen; Christian Lottspeich; Katharina Wang; Matthias K. Auer; Matthias Brendel; Alessa Fischer; Till Braunschweig; Franz-Josef Gilde...; Simon Lindner; Christine Schmid-...; Thomas Pfluger; Christoph J. Auer...; Svenja Nölting; Rudolf A. Werner; Martin Reincke; Martin Bidlingmaier; Matthias Kroiss; Friederike Völter
• Keywords: PET-CT; Chromogranin A; Concordance

Abstracts Background Somatostatin-receptor (SSTR)—targeting PET/CT is widely used for diagnosis and disease monitoring of pheochromocytoma / paraganglioma (PPGL). The aim this study was to assess the potential novel SSTR-targeting tracer [ 18 F]SiTATE in diagnosing PPGL by comparing imaging parameters tumor marker levels secretory activity a small cohort patients diagnosed with rare type. Methods This retrospective included 34 histologically confirmed who underwent F]SiTATE-PET/CT at LMU University Hospital Munich between 10/2020 02/2024 as well hormonal laboratory analysis within up 100 days. Imaging — standardized uptake values (SUVmax, SUVmean), metabolic volume (MTV), total lesion (TLU) were analyzed. Uptake normalized liver background (SUVmaxr, SUVmeanr). Radioligand biochemical subtypes genotypes compared Mann-Whitney-U test. Correlation tested using Spearman´s rank correlation Results patient-based detection rate F]SiTATE-PET 96.6%. A moderate found MTV TLU chromogranin (r = 0.570-0.608, p < 0.005) secretion 0.466-0.576, 0.05). Hereditary Cluster 1 genotype showed stronger sporadic (SUVmeanr: 0.032; SUVmaxr: 0.051). subgroup comparison [⁶⁸Ga]Ga-DOTATOC-PET/CT revealed no significant difference metrics or tumor-to-background ratios. Conclusion first clinical evaluation PPGL. measured correlated serum (nor)metanephrines urine plasma. Within limits imposed cohort, our results suggest that could be SSTR biomarker progression