Diagnostic performance of apparent diffusion coefficient values in differentiating benign from malignant lesions in prostate PI-RADS v2.1 category 1 “nodules in nodule”

• DOI: 10.1007/s00261-025-04930-y
• Publication Date: 2025-04-28T04:16:50Z
• Authors: Minghua Sun; Fei Li; Xiaoyan Zhang; Rui Wu; Wenya Liu; Li Xu; Mengjie Wu; Yangang Wang
• Keywords: Nodule (geology)

To explore the associations between apparent diffusion coefficient (ADC) values of prostate PI-RADS v2.1 category 1 "nodules in nodule" and their pathological characteristics. We retrospectively analyzed images from 226 male patients who underwent biopsy following MRI January 2019 to December 2024. Two radiologists evaluated categories identified nodules, measured ADC nodules a double-blind manner, these characteristics via independent sample t tests or Mann-Whitney U test. The pathologically confirmed as clinically significant cancer (csPCa) were lower than those benign hyperplasia (BPH) ((unit ×10- 3 mm2/s)TZ: 0.739 ± 0.15 versus 0.984 0.24; PZ: 0.719 0.17 1.036 0.21, p < 0.001). AUCs 0.799 (TZ) with cutoff 0.835 × 10- 3mm2/s, 0.873(PZ) 0.795 respectively. total prostate-specific antigen (tPSA), free/t PSA, PSA density (PSAD), gland volume (PGV) differed significantly that csPCa BPH (all 0.05). In nodule", when are less 3mm2/s TZ, score nodule can be upgraded 3.