Tumor-associated myeloid cells promote tumorigenesis of non-tumorigenic human and murine prostatic epithelial cell lines

• DOI: 10.1007/s00262-018-2143-y
• Publication Date: 2018-03-03T07:25:10Z
• Authors: Stephanie N. Sass; Kimberley D. Ramsey; Shawn M. Egan; Jianmin Wang; Eduardo Cortes Gomez; Sandra O. Gollnick
• Keywords: Tumor progression; Tramp; Tumor promotion

The etiology of prostate cancer is poorly understood, but it a multi-step process that has been linked to environmental factors induce inflammation within the gland. Glands patients frequently contain multiple zones disease at various stages progression. drive progression from an indolent benign stage aggressive are not well-defined. Prostate and carcinoma associated with high levels myeloid cell infiltration; these cells in other cancers, their role unclear. To determine whether contribute progression, ability tumor-associated CD11b+ (TAMC) epithelial tumorigenesis was tested. Co-culture TAMC non-tumorigenic genetically primed resulted stable transformation induction tumorigenesis. RNA sequencing identified IL-1α pathway as potential molecular mechanism responsible for tumor promotion by TAMC. Inhibition delayed growth TAMC-induced tumors. Further analysis showed inhibition led decreased angiogenesis tumors, suggesting promotes potentially through augmentation angiogenesis.