Quantitative Assessment of New Frontiers in Dermatochalasis and Periorbital Hyperpigmentation Treatment: The Role of Cross-Linked Porcine Collagen

• DOI: 10.1007/s00266-024-04407-1
• Publication Date: 2024-10-15T18:02:14Z
• Authors: Andy Deng-Chi Chuang; Erh-Ti Lin; Bing-Qi Wu; Meng-En Lu; Hsiu-Mei Chiang; Pai-Nien Chu; Bor-Shyh Lin; Chang-Cheng Chang
• Keywords: Skin hyperpigmentation

Abstract Background Collagen dermal fillers have shown efficacy in addressing age-related changes facial appearance. However, their potential rejuvenating the periorbital region remains unexplored. The aim of this study was to evaluate effectiveness, clinical safety, and patient satisfaction associated with utilization collagen individuals dermatochalasis hyperpigmentation. Methods This reviewed approved by institutional review board China Medical University Hospital (IRB No. CMUH107-REC2-157). Adults diagnosed or hyperpigmentation received injections a sterile cross-linked highly-purified specific antigen free porcine (FACIALGAIN® Implant Lidocaine, Sunmax Biotechnology Co. Ltd., Taipei, Taiwan) were assessed for hydration, elasticity, pigmentation index, redness lightness value, density DermaLab® Combo Multiparameter Skin Analysis System (Cortex Technology, Hadsund, Denmark) Cutometer® Dual MPA 580 (Courage+Khazaka electronic GmbH, Köln, Germany). Data collected prior injection at 1 week, 4 weeks, 12 weeks after injection. Patient on volume augmentation, decrease hyperpigmentation, persistence, overall also recorded. Results A total samples each recruited For subjects, hydration tissue significantly increased week ( p = 0.011 0.015). Elasticity decreased persisted until 0.001 0.014). patients, value starting 0.016), tapering off 12. 0.002 0.002). Median out 5 group 4.5 group, mild but insignificant Conclusions are considered effective methods evaluating patients undergoing filler injections. can serve as minimally invasive approach enhance skin laxity address discoloration it is important note that regular treatments may be necessary sustain desired outcomes. Level Evidence IV journal requires authors assign level evidence article. full description these Evidence-Based Medicine ratings, please refer Table Contents online Instructions Authors www.springer.com/0026 .