Treatment Planning and Volumetric Response Assessment for Yttrium-90 Radioembolization: Semiautomated Determination of Liver Volume and Volume of Tumor Necrosis in Patients with Hepatic Malignancy

• DOI: 10.1007/s00270-010-9938-3
• Publication Date: 2010-08-03T20:29:51Z
• Authors: Wayne L. Monsky; Armando S. Garza; Isaac Kim; Shaun Loh; Tzu-Chun Lin; Chin-Shang Li; Jerron Fisher; Parmbir Sandhu; Vishal Sidhar; Abhijit J. Chaudhari; Frank Lin; Larry-Stuart Deutsch; Ramsey D. Badawi
• Keywords: Coagulative necrosis

The primary purpose of this study was to demonstrate intraobserver/interobserver reproducibility for novel semiautomated measurements hepatic volume used Yttrium-90 dose calculations as well whole-liver and necrotic-liver (hypodense/nonenhancing) tumor after radioembolization. secondary aim provide initial comparisons volumetric with linear measurements, defined by Response Evaluation Criteria in Solid Tumors criteria, survival outcomes. Between 2006 2009, 23 consecutive radioembolization procedures were performed 14 cases hepatocellular carcinoma 9 metastases. Baseline follow-up computed tomography obtained 1 month treatment retrospectively analyzed. Three observers measured liver, whole-tumor, tumor-necrosis volumes twice using software. Good demonstrated (intraclass correlation [ICC] > 0.9) liver volumes. Semiautomated statistically similar those manual tracing (ICC = 0.868), but they required significantly less time perform (p < 0.0001, ICC 0.088). There a positive association between change whole-tumor 0.0001). However, did not correlate necrosis 0.05). Dose, diameters, volume, necrotic 0.05 all instances). Kaplan–Meier curves suggest that >10% increase correlated 0.0472). analysis can be good reproducibility. In small retrospective study, suggested survival.