Fatigue at baseline is associated with geriatric impairments and represents an adverse prognostic factor in older patients with a hematological malignancy

• DOI: 10.1007/s00277-018-3420-8
• Publication Date: 2018-07-28T01:07:40Z
• Authors: F. Hofer; K. A. Koinig; L. Nagl; B. Borjan; R. Stauder
• Keywords: Depression; Chronic Fatigue; Performance status; Hematology; Geriatric Depression Scale

Prospective data on fatigue in elderly persons with a hematological malignancy are rare. We aimed to determine the prevalence of and its association clinical outcome geriatric impairments older individuals newly diagnosed blood cancer. The EORTC QLQ-C30 multidimensional assessment (MGA) were performed parallel 149 consecutive patients aged > 67 years (median 77.8 years) at Innsbruck Medical University between January 2009 April 2016. Fatigue as defined by was most prevalent symptom (84%) significantly associated self-reported role physical functioning, global health status insomnia, dyspnea, loss appetite (p < 0.001). Remarkably, pronounced impaired performance objective functional capacities MGA, altered depression scoring, G8 screening, elevation serum inflammation markers Patients minor had median overall survival (OS) 26.4 months, whereas those marked displayed an OS 7.0 months shortened supported multivariate analyses (HR 1.74, CI 1.09-2.76; p = 0.021). is seen have high be adverse prognostic factor malignancy. strong impact emphasizes relevance patient-reported outcomes individualized treatment algorithms. will benefit from identification fatigue, allowing timely interventions. correlation performance, nutritional status, might suggest underlying common pathway.