A phase I study to determine the pharmacokinetics and urinary excretion of belinostat and metabolites in patients with advanced solid tumors

• DOI: 10.1007/s00280-016-3167-7
• Publication Date: 2016-10-15T11:24:10Z
• Authors: Hanna Bailey; Jordan P. McPherson; Erin B. Bailey; Theresa L. Werner; Sumati Gupta; Julia Batten; Guru Reddy; Gajanan Bhat; Sunil Sharma; Neeraj Agarwal
• Keywords: Adult; Male; Sulfonamides; Dose-Response Relationship, Drug; Middle Aged; Hydroxamic Acids; Disease-Free Survival; 6. Clean water; 3. Good health; Histone Deacetylase Inhibitors; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Area Under Curve; Neoplasms; Disease Progression; Humans; Female; Infusions, Intravenous; Biotransformation; Aged

Belinostat is an inhibitor of histone deacetylase enzymes, resulting in DNA repair inhibition and apoptosis. Present data are lacking to provide dosing recommendations in renal insufficiency. The purpose of this trial was to assess the pharmacokinetics (PK) of belinostat and belinostat metabolites in plasma and urine.This was a phase I, single-center, open-label, two-part study. In Part I, patients received single-agent belinostat 1000 mg/m2. Blood and urine samples were collected at pre-specified time points to determine PK of belinostat and metabolites and their elimination in urine. In Part II, patients were permitted to continue belinostat in 21-day cycles on Days 1 through 5 until disease progression, unacceptable toxicity, or according to patient preference.A total of nine patients with advanced solid tumors were treated. Median t max for belinostat was observed 10 min after the start of infusion. Concentrations of belinostat rapidly declined with a t 1/2 of 2.9 h. The mean fraction of belinostat excreted unchanged in urine was 0.926 %. The metabolites belinostat glucuronide and 3-ASBA represented the largest fractions of belinostat dose excreted in urine (30.5 and 4.61 %, respectively), while renal excretion appeared to be a minor route of elimination for the parent belinostat (<1 %). The most common adverse events were nausea, fatigue, and diarrhea. One Grade 3 adverse event (constipation) was thought to be treatment related.Urinary elimination of parent belinostat was minimal, although a combined 36.7 % of belinostat metabolites were excreted in urine. Since these metabolites are primarily inactive, belinostat may not require dosage adjustment in renal dysfunction.