Lack of association of -607 C/A and -137 G/C polymorphisms in interleukin 18 gene with susceptibility to gout disease in Chinese Han male population

• DOI: 10.1007/s00296-011-1936-5
• Publication Date: 2011-04-12T05:50:14Z
• Authors: Changgui Li; Ying Yuan; Xinfeng Wang; Lin Han; Nan Chu; Hui Wang; Shiguo Liu
• Keywords: Male; 0301 basic medicine; China; Chi-Square Distribution; Polymorphism, Genetic; Gout; Short Communication; Immunology; Interleukin-18; Polymerase Chain Reaction; Risk Assessment; 3. Good health; 03 medical and health sciences; Phenotype; Rheumatology; Asian People; Gene Frequency; Risk Factors; Case-Control Studies; Immunology and Allergy; Humans; Genetic Predisposition to Disease; Promoter Regions, Genetic

To identify association of IL18-607 C/A and -137 G/C polymorphism with susceptibility to gout in Chinese Han male population, We evaluate the genetic contribution of the IL18-607 C/A and -137 G/C polymorphism in 202 gout male patients and 493 gout-free control of Chinese Han population by allele-specific polymerase chain reaction assay. Our results reveal no significant association between the polymorphisms -607C/A and -137G/C in IL18 with gout. Our study might suggest that -607 C/A and -137 G/C polymorphisms in the promoter of IL18 are not associated with susceptibility to gout and thus do not play a major role in the development of gout in the Chinese Han male population.