Differences and similarities of multisystem inflammatory syndrome in children, Kawasaki disease and macrophage activating syndrome due to systemic juvenile idiopathic arthritis: a comparative study
leukocyte count
Juvenile
Observational Research
0302 clinical medicine
aspartate aminotransferase
Systemic juvenile idiopathic arthritis
League
Child
child
Macrophage Activation Syndrome
Multisystem inflammatory syndrome in children (MIS-C)
Heart
Shock
Systemic Juvenile Idiopathic Arthritis
biological marker
Classification
Systemic Inflammatory Response Syndrome
3. Good health
systemic inflammatory response syndrome
female
Macrophage activation syndrome
Kawasaki disease (KD)
D dimer
Covid-19
hospitalization
alanine aminotransferase
610
complication
macrophage
Mucocutaneous Lymph Node Syndrome
brain natriuretic peptide
Multisystem Inflammatory Syndrome In Children (Mis-C)
Article
618
03 medical and health sciences
male
mucocutaneous lymph node syndrome
juvenile rheumatoid arthritis
Humans
controlled study
human
lymphocyte count
human cell
neutrophil count
Arthritis
Macrophages
ferritin
COVID-19
hemoglobin
platelet count
major clinical study
Arthritis, Juvenile
ferritin blood level
thrombocyte
inflammation
Ferritins
Kawasaki Disease (Kd)
Biomarkers
DOI:
10.1007/s00296-021-04980-7
Publication Date:
2021-09-07T08:02:50Z
AUTHORS (46)
ABSTRACT
To compare the clinical and laboratory findings of multisystem inflammatory syndrome in children (MIS-C), patients with Kawasaki disease (KD) and with macrophage activating syndrome due to systemic juvenile idiopathic arthritis (sJIA-MAS) on real-life data. Patients diagnosed with MIS-C, KD, and sJIA-MAS from 12 different centers in Turkey who were followed for at least 6 months were included in the study. Demographic, clinical, and laboratory findings of all patients were analyzed. A total of 154 MIS-C, 59 KD, and 31 sJIA-MAS patients were included. The median age of patients with MIS-C were higher than those with KD while lower than those with sJIA-MAS (8.2, 3, 12 years, respectively). Myalgia (39.6%), cardiac (50.6%), gastrointestinal (72.7%), and neurological (22.1%) involvements were more common in patients with MIS-C compared to others. MIS-C patients had lower levels of lymphocyte (950 vs 1700 cells/µl) and thrombocyte (173,000 vs 355,000 cells/µl) counts and higher pro-BNP (1108 vs 55 pg/ml) levels than KD. Ferritin levels were higher in patients with MIS-C compared to patients with KD while they were lower than patients with sJIA-MAS (440, 170, 10,442 ng/ml, respectively). Patients with MIS-C had a shorter duration of hospitalization than sJIA-MAS (p = 0.02) while they required intensive care unit admission more frequently (55 vs 8 patients, p < 0.001). The median MAS/sJIA score of MIS-C patients was - 1.64 (- 5.23 to 9.68) and the median MAS/sJIA score of sJIA-MAS patients was -2.81 ([- 3.79] to [- 1.27]). MIS-C patients displayed certain differences in clinical and laboratory features when compared to KD and sJIA-MAS. Definition of the differences and similarities between MIS-C and the other intense inflammatory syndromes of childhood such as KD and MAS will help the clinicians while making timely diagnosis.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (40)
CITATIONS (39)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....