COVID-19 severity and vaccine breakthrough infections in idiopathic inflammatory myopathies, other systemic autoimmune and inflammatory diseases, and healthy controls: a multicenter cross-sectional study from the COVID-19 Vaccination in Autoimmune Diseases (COVAD) survey

• DOI: 10.1007/s00296-022-05229-7
• Publication Date: 2022-10-22T08:02:46Z
• Authors: Leonardo Santos Hoff; Naveen Ravichandran; Samuel Katsuyuki ...; Jessica Day; Parikshit Sen; Jucier Gonçalves ...; James B. Lilleker; Mrudula Joshi; Vishwesh Agarwal; Sinan Kardes; Minchul Kim; Marcin Milchert; Ashima Makol; Tamer Gheita; Babur Salim; Tsvetelina Velikova; Abraham Edgar Gra...; Ioannis Parodis; Albert Selva O’Ca...; Elena Nikiphorou; Ai Lyn Tan; Tulika Chatterjee; Lorenzo Cavagna; Miguel A. Saavedra; Nelly Ziade; Johannes Knitza; Masataka Kuwana; Arvind Nune; Oliver Distler; Döndü Üsküdar Cansu; Lisa Traboco; Suryo Angorro Kus...; Erick Adrian Zamo...; Jorge Rojas Serrano; Ignacio García-De...; Chris Wincup; John D. Pauling; Hector Chinoy; Vikas Agarwal; Rohit Aggarwal; Latika Gupta
• Keywords: Cross-sectional study

Abstract Objectives We aimed to compare the spectrum and severity of COVID-19 vaccine breakthrough infections (BIs) among patients with IIMs, other systemic autoimmune inflammatory diseases (SAIDs), healthy controls (HCs). Methods This is a cross-sectional study data from COVAD study, self-reported online global survey that collected demographics, history, vaccination details April September 2021. Adult at least one dose were included. BIs defined as occurring > 2 weeks after any vaccine. Characteristics associated BI analyzed multivariate regression analysis. Results Among 10,900 respondents [42 (30–55) years, 74%-females, 45%-Caucasians] HCs (47%), SAIDs (42%) IIMs (11%). Patients reported fewer cases before (6.2%-IIM vs 10.5%-SAIDs 14.6%-HC; OR = 0.6, 95% CI 0.4–0.8, 0.3, 0.2–0.5, respectively). uncommon (1.4%-IIM; 1.9%-SAIDs; 3.2%-HC) occurred in 17 IIM patients, 13 whom on immunosuppressants, 3(18%) required hospitalization. All-cause hospitalization was higher compared [23 (30%) 59 (8%), 2.5, 1.2–5.1 vaccination, 3 (18%) 9 (5%), 2.6, 1.3–5.3 BI]. In analysis, age 30–60 years lower odds (OR 0.7, 0.5–1.0), while use immunosuppressants had 1.6, 1.1–2.7). Conclusions than SAIDs, but all-cause HCs. IIMs.