The prevalence of neutropenia and association with infections in patients with systemic lupus erythematosus: a Swedish single-center study conducted over 14 years

• DOI: 10.1007/s00296-024-05566-9
• Publication Date: 2024-03-19T06:51:21Z
• Authors: Muna Saleh; Johanna Sjöwall; Marcus Bendtsen; Christopher Sjöwall
• Keywords: Leukopenia; Medical record; Single Center

Abstract Hematologic abnormalities are common manifestations of SLE, although neutropenia is observed less frequently and not included in the classification criteria. Nonetheless, a risk factor for infections, especially those caused by bacteria or fungi. We aimed to evaluate impact SLE through systematic investigation all infections large cohort well-characterized patients, focusing on neutropenia, lymphopenia, hypocomplementemia. Longitudinal clinical laboratory parameters obtained at visits Rheumatology Unit, Linköping University Hospital, linked data forms healthcare utilization subjects our regional register during 2008–2022 were assessed. Data regarding confirmed retrieved from medical records. Overall, 333 patients monitored 3,088 rheumatologist study period. In total, 918 identified, 94 occasions (ANC < 1.5 × 10 9 /L) detected 40 (12%). Thirty neutropenic episodes 15 occurred association with which 13 (43%) required in-hospital care, 4 (13%) needed intensive 1 (3%) resulted death. Bayesian analysis showed that ≥ occasion more likely experience one (OR = 2.05; probability [POA] 96%). Both invasiveness 7.08; POA 98%) severity 2.85; 96%) significantly associated present neutropenia. Infections among Swedish 12% whom show over time. Importantly, both infections. Awareness risks severe crucial tailor therapies prevent illness