COVID-19 vaccination-related delayed adverse events among people with rheumatoid arthritis: results from the international COVAD survey

• DOI: 10.1007/s00296-024-05742-x
• Publication Date: 2024-11-06T09:07:02Z
• Authors: Mrinalini Dey; Bohdana Doskaliuk; Ioannis Parodis; Julius Lindblom; Chris Wincup; Mrudula Joshi; Dzifa Dey; Wanruchada Katcha...; Esha Kadam; Parikshit Sen; Samuel Katsuyuki ...; Arvind Nune; Phonpen Akarawatc...; Nelly Ziade; Yi Ming Chen; Lisa S. Traboco; Carlos Enrique To...; Binit Vaidya; Vikas Agarwal; Latika Gupta; Elena Nikiphorou; ; R Naveen; Sreoshy Saha; Ai Lyn Tan; Masataka Kuwana; Akira Yoshida; Keina Yomono; John D. Pauling; Ashima Makol; Jessica Day; Tulika Chatterjee; Lorenzo Cavagna; Vishwesh Agarwal; Marcin Milchert; Oliver Distler; Hector Chinoy; Tsvetelina Valikova; Abraham Edgar Gra...; Johannes Knitza; Aarat Patel; Bhupen Barman; Erick Adrian Zamo...; Jorge Rojas Serrano; Ignacio García-De...; Iris J. Colunga-P...; Javier Merayo-Cha...; Okwara Celestine ...; Russka Shumnalieva; Leonardo Santos Hoff; Lina Kibbi; Hussein Halabi; A. T. M Tanveer H...; Carlo V. Caballer...; James B. Lilleker; Babur Salim; Tamer Gheita; Miguel A. Saavedra; Sinan Kardes; Laura Andreoli; Daniele Lini; Karen Schreiber; Melinda Nagy Vince; Yogesh Preet Singh; Rajiv Ranjan; Avinash Jain; Sapan C. Pandya; Rakesh Kumar Pilania; Aman Sharma; M. Manesh Manoj; Vikas Gupta; Chengappa G. Kava...; Pradeepta Sekhar ...; Sajal Ajmani; Sanat Phatak; Rudra Prosad Goswami; Abhra Chandra Cho...; Ashish Jacob Mathew; Padnamabha Shenoy; Ajay Asranna; Keerthi Talari Bo...; Anuj Shukla; Arunkumar R. Pande; Kunal Chandwar; Akanksha Ghodke; Hiya Boro; Zoha Zahid Fazal; Döndü Üsküdar Cansu; Reşit Yıldırım; Armen Yuri Gasparyan; Nicoletta Papa; Gianluca Sambataro; Atzeni Fabiola; Marcello Govoni; Simone Parisi; Elena Bartoloni B...; Gian Domenico Seb...; Enrico Fusaro; Marco Sebastiani; Luca Quartuccio; Franco Franceschini; Pier Paolo Sainaghi; Giovanni Orsolini; Rossella Angelis; Maria Giovanna Da...; Vincenzo Venerito; Silvia Grignaschi; Alessandro Giollo; Alessia Alluno; Florenzo Ioannone; Marco Fornaro; Suryo Anggoro Kus...; Jesús Loarce-Martos; Sergio Prieto-Gon...; Raquel Aranega Go...; Ran Nakashima; Shinji Sato; Naoki Kimura; Yuko Kaneko; Takahisa Gono; Stylianos Tomaras; Fabian Nikolai Proft; Marie-Therese Holzer; Margarita Aleksan...; Or Aharonov; Zoltán Griger; Ihsane Hmamouchi; Imane bouchti; Zineb Baba; Margherita Giannini; François Maurier; Julien Campagne; Alain Meyer; Daman Langguth; Vidya Limaye; Merrilee Needham; Nilesh Srivastav; Marie Hudson; Océane Landon-Car...; Wilmer Gerardo Ro...; Álvaro Arbeláez; Javier Cajas; José António Pere...; João Eurico Fonseca; Olena Zimba; Doskaliuk Bohdana; Uyi Ima-Edomwonyi; Ibukunoluwa Dedeke; Emorinken Airenakho; Nwankwo Henry Madu; Abubakar Yerima; Hakeem Olaosebikan; A. Becky; Oruma Devi Kousso...; Elisa Palalane; Ho So; Manuel Francisco ...; Lyn Chinchay; José Proaño Bernaola; Victorio Pimentel; Hanan Mohammed Fathi; Reem Hamdy A. Moh...; Ghita Harifi; Yurilís Fuentes-S...; Karoll Cabriza; Jonathan Losanto; Nelly Colaman; Antonio Cachafeir...; Generoso Guerra B...; Enrique Julio Gir...; Lilith Stange Nunez; Vergara M. Cristian; Jossiell Then Báez; Hugo Alonzo; Carlos Benito San...; Rodrigo García Sa...; Alejandro Quiñóne...; Nilmo Chávez; Andrea Bran Ordóñez; Gil Alberto Reyes...; Radames Sierra-Zo...; Dina Arrieta; Eduardo Romero Hi...; Ricardo Saenz; Escalante M. Idania; Wendy Calapaqui; Ivonne Quezada; Gabriela Arredondo
• Keywords: 2403 Immunology; 2745 Rheumatology; Coronaviru; Vaccination; 10051 Rheumatology Clinic and Institute of Physical Medicine; COVID-19; 610; 610 Medicine & health; Observational Research; 03 medical and health sciences; 0302 clinical medicine; 616; 2723 Immunology and Allergy; Coronavirus; Rheumatoid arthritis; Survey; Vaccination.; Survey; Rheumatoid arthriti

AbstractThis study aimed to assess COVID-19 vaccination-related AEs in patients with rheumatoid arthritis (RA), in the COVID-19 Vaccination in Autoimmune Diseases (COVAD)-2 study. An online international cross-sectional survey captured self-reported data on COVID-19 vaccination-related adverse events (AEs) in people with RA, autoimmune diseases (AIDs; rheumatic [r] and non-rheumatic [nr]) and healthy controls (HCs). The survey was circulated by the COVAD study group, comprising 157 collaborators across 106 countries, from February to June 2022. Delayed AEs among RA were compared with other rAIDs, nrAIDs and HCs using multivariable binary regression. A total of 7203 participants were included (1423 [19.7%] RA, 2620 [36.4%] rAIDs, 426 [5.9%] nrAIDs, 2734 [38%] HCs), with 75% female. Compared to HCs, individuals with RA reported higher overall major AEs [OR 1.3 (1.0–1.7)], and an increased number of several minor AEs. Compared to nrAIDs, people with RA had several increased reported minor AEs including myalgia and joint pain. People with active RA had increased major AEs [OR 1.8 (1.1–3.0)] and hospitalisation [OR 4.1 (1.3 – 13.3)] compared to inactive RA. RA patients without autoimmune comorbidities had significantly fewer major and minor AEs than those with other rAIDs. A decreased incidence of hospitalisation was seen in patients taking methotrexate or TNF inhibitors compared to patients not taking these medications. COVID-19 vaccination is associated with minimal to no risks of delayed AEs in patients with RA compared to HCs, and fewer compared to other rAIDs. Active RA and presence of co-existing rAIDs were associated with an increased risk of delayed AEs.