Image registration improves human knee cartilage T1 mapping with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC)

• DOI: 10.1007/s00330-012-2590-3
• Publication Date: 2012-08-03T03:25:03Z
• Authors: Esther E. Bron; Jasper van Tiel; Henk Smit; Dirk H. J. Poot; Wiro J. Niessen; Gabriel P. Krestin; Harrie Weinans; Edwin H. G. Oei; Gyula Kotek; Stefan Klein
• Keywords: Neuroradiology; Interventional radiology; Knee cartilage

To evaluate the effect of automated registration in delayed gadolinium-enhanced MRI cartilage (dGEMRIC) knee on occurrence movement artefacts T1 map and reproducibility region-of-interest (ROI)-based measurements. Eleven patients with early-stage osteoarthritis ten healthy controls underwent dGEMRIC twice at 3 T. Controls unenhanced imaging. ROIs were manually drawn femoral tibial cartilage. calculation was performed without T1-weighted images. Automated three-dimensional rigid femur tibia separately. Registration quality evaluated using square root Cramér–Rao lower bound (CRLBσ). Additionally, assessed by comparing manual slice-matching. images improved maps as 90% percentile CRLBσ significantly (P < 0.05) reduced a median reduction 55.8 ms (patients) 112.9 (controls). Manual matching re-imaged gave comparable intraclass correlation coefficients respectively 0.89/0.90 0.85/0.85 reduces provides good alternative to slice-matching longitudinal studies. • Quantitative is increasingly used for biomedical assessment articular Image leads more accurate quantification damage Movement are image successfully aligns baseline follow-up examinations Reproducibility similar that