Apparent diffusion coefficient for molecular subtyping of non-gadolinium-enhancing WHO grade II/III glioma: volumetric segmentation versus two-dimensional region of interest analysis

• DOI: 10.1007/s00330-018-5351-0
• Publication Date: 2018-03-23T11:48:41Z
• Authors: S. C. Thust; S. Hassanein; S. Bisdas; J. H. Rees; H. Hyare; J. A. Maynard; S. Brandner; C. Tur; H. R. Jäger; T. A. Yousry; L. Mancini
• Keywords: Isocitrate dehydrogenase; Neuroradiology; Coefficient of variation

To investigate if quantitative apparent diffusion coefficient (ADC) measurements can predict genetic subtypes of non-gadolinium-enhancing gliomas, comparing whole tumour against single slice analysis. Volumetric T2-derived masks 44 gliomas were co-registered to ADC maps with mean (ADCmean) calculated. For the analysis, two observers placed regions interest in largest cross-section. The ratio (ADCratio) between ADCmean and normal appearing white matter was calculated for both methods. Isocitrate dehydrogenase (IDH) wild-type showed lowest values throughout (p < 0.001). IDH-mutant 1p19q intact group significantly higher than co-deleted 0.01). A volumetric threshold 1201 × 10−6 mm2/s identified IDH a sensitivity 83% specificity 86%; ADCratio cut-off value 1.65 provided 80% 92% (area under curve (AUC) 0.9–0.94). observer 1 (observer 2) 1.76 (1.83) (86%), 91% (100%) AUC 0.95 (0.96). intraclass correlation excellent (0.98). support distinction glioma subtypes. two-dimensional yielded similar results this study. • Diffusion-weighted MRI aids identification malignant may permit molecular subtyping have lower tumours Single cross-section comparable study