Comparison of a coaxial versus non-coaxial liver biopsy technique in an oncological setting: diagnostic yield, complications and seeding risk

• DOI: 10.1007/s00330-020-07038-7
• Publication Date: 2020-07-14T06:22:02Z
• Authors: Nicos Fotiadis; Katja N. De Paepe; Lawrence Bonne; Nasir Khan; Angela Riddell; Nicholas Turner; Naureen Starling; Marco Gerlinger; Sheela Rao; Ian Chau; David Cunningham; Dow-Mu Koh
• Keywords: Interventional radiology

Abstract Objectives Percutaneous liver biopsy (PLB) poses specific challenges in oncological patients such as bleeding and tumour seeding. This study’s aim was to compare a coaxial (C-PLB) non-coaxial (NC-PLB) technique terms of diagnostic yield, safety seeding risk image-guided PLB techniques an setting. Methods Local research committee approval obtained for this single-site retrospective study. Patients who underwent between November 2011 December 2017 were consecutively included. Medical records reviewed determine yield complications. Follow-up imaging re-reviewed seeding, defined visible deposits along the track. Mann-Whitney U chi-squared tests performed investigate differences sample number, complications rate. Results In total, 741 (62 ± 13 years, 378 women) 932 (C-PLB 72.9% (679/932); NC-PLB 27.1% (253/932)). More tissue cores ( p < 0.001) with C-PLB (median 4 cores; range 1–12) compared (2 1–4) similar both 92.6% (629/679); 92.5% (234/253); = 0.940). Complication rate (9.3%; 87/932) using (8.2% (56/679)) lower (12.3% (31/253); 0.024). Major uncommon 2.7% (18/679); 2.8% (7/253)); developed 1.2% (11/932; (8/679); (3/253)). Seeding rare event, occurring significantly less cases 1.3% (7/544); 3.1% (6/197); 0.021). Conclusions allows high complication than should be preferred method Key Points • A percutaneous achieves significant higher number fewer technique. The is very low study , larger median ) could safely acquired providing sufficient material advanced molecular analysis.