Magnetic resonance parametric mapping of the spleen for non-invasive assessment of portal hypertension

• DOI: 10.1007/s00330-020-07080-5
• Publication Date: 2020-08-04T12:02:36Z
• Authors: Narine Mesropyan; Alexander Isaak; Anton Faron; Michael Praktiknjo; Christian Jansen; Daniel Kuetting; Carsten Meyer; Claus C. Pieper; Alois M. Sprinkart; Johannes Chang; Burkhard Maedler; Daniel Thomas; Patrick Kupczyk; Ulrike Attenberger; Julian A. Luetkens
• Keywords: Hepatic Encephalopathy; Neuroradiology; Liver disease; Interventional radiology; Portosystemic shunt; Portal venous system

Abstract Objectives In patients with advanced liver disease, portal hypertension is an important risk factor, leading to complications such as esophageal variceal bleeding, ascites, and hepatic encephalopathy. This study aimed determine the diagnostic value of T1 T2 mapping extracellular volume fraction (ECV) for non-invasive assessment hypertension. Methods this prospective study, 50 participants (33 indication trans-jugular intrahepatic portosystemic shunt (TIPS) 17 healthy volunteers) underwent MRI. The derivation validation cohorts included 40 10 participants, respectively. relaxation times ECV spleen were assessed using quantitative techniques. Direct venous pressure gradient (HVPG) measurements performed during TIPS procedure. ROC analysis was compare performance. Results Splenic correlated ( r = 0.72; p < 0.001) direct HVPG 0.50; 0.003). No significant correlations found between native splenic > 0.05, respectively). cohort, revealed a perfect performance AUC 1.000 identification clinically (direct ≥ mmHg) outperformed other parameters: (AUC, 0.731), 0.736), 0.806) parameters comparable in cohort. Conclusion associated disease. Future studies should explore parametric accross broader range values. Key Points • Non-invasive monitoring area unmet interest. strongly end-stage Quantitative MRI-derived have potential become new parameter assess monitor pressure.