Multimodal photoacoustic/ultrasonic imaging system: a promising imaging method for the evaluation of disease activity in rheumatoid arthritis

• DOI: 10.1007/s00330-020-07353-z
• Publication Date: 2020-11-12T07:02:39Z
• Authors: Chenyang Zhao; Qian Wang; Xixi Tao; Ming Wang; Chen Yu; Sirui Liu; Mengtao Li; Xinping Tian; Zhenhong Qi; Jianchu Li; Fang Yang; Lei Zhu; Xujin He; Xiaofeng Zeng; Yuxin Jiang; Meng Yang
• Keywords: Neuroradiology

Abstract Objectives We aimed to assess the clinical value of multimodal photoacoustic/ultrasound (PA/US) articular imaging scores, a novel method which can reflect micro-vessels and oxygenation level inflamed joints rheumatoid arthritis (RA). Methods Seven small were examined by PA/US system. A 0–3 scoring system was used semi-quantify PA power-Doppler (PD) signals, sums PD scores (PA-sum PD-sum scores) seven calculated. The relative oxygen saturation (SO 2 ) values measured classified into 3 PA+SO patterns. correlations between disease activity assessed. Results Thirty-one patients RA total 217 using PA-sum had high positive with standard (DAS28 [ESR] ρ = 0.754, DAS28 [CRP] 0.796, SDAI 0.836, CDAI 0.837, p < 0.001), superior 0.651, 0.676, 0.716, 0.709, 0.001). For significant differences hypoxia hyperoxia identified in pain visual analog score ( 0.020) patient’s global assessment 0.026). patterns presented moderate correlation PGA 0.477, 0.0077) VAS 0.717, Conclusion have for RA, are also related that severity. may potential evaluating RA. Key Points • Multimodal is local lesions. Significant parameters verified. provide objective parameters, including SO value, as supplementary evaluation.