Cardiac magnetic resonance T1 mapping for evaluating myocardial fibrosis in patients with type 2 diabetes mellitus: correlation with left ventricular longitudinal diastolic dysfunction

• DOI: 10.1007/s00330-022-08800-9
• Publication Date: 2022-05-14T08:03:01Z
• Authors: Xi Liu; Yue Gao; Ying-Kun Guo; Chun-Chao Xia; Rui Shi; Li Jiang; Meng-Ting Shen; Lin-Jun Xie; Wan-Lin Peng; Wen-Lei Qian; Ming-Yan Deng; Li-Ling Deng; Yan Ren; Zhi-Gang Yang
• Keywords: Magnetic Resonance Spectroscopy; Myocardium; Magnetic Resonance Imaging, Cine; Fibrosis; Ventricular Function, Left; Ventricular Dysfunction, Left; 03 medical and health sciences; 0302 clinical medicine; Diabetes Mellitus, Type 2; Predictive Value of Tests; Humans; Cardiomyopathies

We aimed to evaluate myocardial fibrosis using cardiac magnetic resonance (CMR) T1 mapping in type 2 diabetes mellitus (T2DM) patients and investigate the association between left ventricular (LV) subclinical myocardial dysfunction and myocardial fibrosis.The study included 37 short-term (≤ 5 years) and 44 longer-term (> 5 years) T2DM patients and 41 healthy controls. The LV global strain parameters and T1 mapping parameters were compared between the abovementioned three groups. The association of T1 mapping parameters with diabetes duration, in addition to other risk factors, was determined using multivariate linear regression analysis. The correlation between LV strain parameters and T1 mapping parameters was evaluated using Pearson's correlation.The peak diastolic strain rates (PDSRs) were significantly lower in longer-term T2DM patients compared to those in healthy subjects and short-term T2DM patients (p < 0.05). The longitudinal peak systolic strain rate and peak strain were significantly lower in the longer-term T2DM compared with the short-term T2DM group (p < 0.05). The extracellular volumes (ECVs) were higher in both subgroups of T2DM patients compared with control subjects (all p < 0.05). Multivariate linear regression analysis showed that diabetes duration was independently associated with ECV (β = 0.413, p < 0.001) by taking covariates into account. Pearson's analysis showed that ECV was associated with longitudinal PDSR (r = - 0.441, p < 0.001).T1 mapping could detect abnormal myocardial fibrosis early in patients with T2DM, which can cause a decline in the LV diastolic function.• CMR T1 mapping could detect abnormal myocardial fibrosis early in patients with T2DM. • The diabetes duration was independently associated with ECV. • Myocardial fibrosis can cause a decline in the LV diastolic function in T2DM patients.