Periprostatic fat measured on computed tomography as a marker for prostate cancer aggressiveness

• DOI: 10.1007/s00345-009-0497-7
• Publication Date: 2009-12-21T12:54:20Z
• Authors: Joep G. H. van Ro...; Gijsbert H. Bol; J. Alfred Witjes; J. L. H. Ruud Bosch; Lambertus A. Kiem...; Marco van Vulpen
• Keywords: Male; Urology; Brachytherapy; Body Mass Index; 03 medical and health sciences; 0302 clinical medicine; Biomarkers, Tumor; Body Fat Distribution; Humans; NCEBP 2: Evaluation of complex medical interventions; ONCOL 4: Quality of Care; Aged; Retrospective Studies; Aged, 80 and over; 2. Zero hunger; Prostatic Neoplasms; Middle Aged; NCEBP 1: Molecular epidemiology; ONCOL 5: Aetiology, screening and detection; 3. Good health; Treatment Outcome; ONCOL 3: Translational research; Adipose Tissue; Disease Progression; Original Article; Tomography, X-Ray Computed

Several reports found that obesity was associated with prostate cancer (PC) aggressiveness among men treated radical prostatectomy or radiotherapy. Studies concerning this issue have basically relied on body mass index (BMI), as a marker for general obesity. Because visceral fat is the most metabolic active fat, we sought to evaluate if periprostatic measured computed tomography (CT) better than BMI predict PC in Dutch population who underwent brachytherapy localized PC.Of 902 patients brachytherapy, 725 CT scans were available. Subcutaneous thickness (CFT), area (cm(2)) and fat-density (%) determined scan. Patients stratified into three groups: <25, 25-75 >75 percentile of fat-density. Associations between subgroups examined.237 classified having normal weight (37.2%), 320 overweight (50.2%) 80 obese (12.6%). There strong significant association CFT. The strongest correlation seen CFT (Pearson r coefficient = 0.71). Logistic regression analysis revealed no statistically different measurements risk high-risk disease.Periprostatic not correlated receiving brachytherapy. However, 31% had