Prognostic value of temporal patterns of left atrial reservoir strain in patients with heart failure with reduced ejection fraction

• DOI: 10.1007/s00392-023-02244-x
• Publication Date: 2023-06-13T17:01:36Z
• Authors: S. Abou Kamar; Y. S. Aga; M. de Bakker; V. J. van den Berg; M. Strachinaru; D. Bowen; R. Frowijn; K. M. Akkerhuis; J. J. Brugts; O. Manintveld; V. Umans; M. Geleijnse; R. A. de Boer; E. Boersma; I. Kardys; B. M. van Dalen
• Keywords: Speckle tracking echocardiography; Clinical endpoint

Abstract Background We investigated whether repeatedly measured left atrial reservoir strain (LASr) in heart failure with reduced ejection fraction (HFrEF) patients provides incremental prognostic value over a single baseline LASr value, and temporal patterns of provide other echocardiographic markers NT-proBNP. Methods In this prospective observational study, 153 underwent 6-monthly echocardiography, during median follow-up 2.5 years. Speckle tracking echocardiography was used to measure LASr. Hazard ratios (HRs) were calculated for from Cox models (baseline) joint (repeated measurements). The primary endpoint (PEP) comprised HF hospitalization, ventricular assist device, transplantation, cardiovascular death. Results Mean age 58 ± 11 years, 76% men, 82% NYHA class I/II, mean 20.9% 11.3%, LVEF 29% 10%. PEP reached by 50 patients. Baseline repeated measurements (HR per SD change (95% CI) 0.20 (0.10–0.41) (0.13 (0.10–0.29), respectively) both significantly associated the PEP, independent echo-parameters Although persistently lower time trajectories did not diverge versus without as approached. Conclusion adverse events HFrEF patients, Temporal showed decreased but stable values do clinical practice compared Graphical abstract