Sex-related differences in patients presenting with heart failure–related cardiogenic shock

• DOI: 10.1007/s00392-024-02392-8
• Publication Date: 2024-02-14T09:02:21Z
• Authors: Jonas Sundermeyer; Caroline Kellner; Benedikt N. Beer; Lisa Besch; Angela Dettling; Letizia Fausta Be...; Stefan Blankenberg; Jeroen Dauw; Zouhir Dindane; Dennis Eckner; Ingo Eitel; Tobias Graf; Patrick Horn; Joanna Jozwiak-No...; Paulus Kirchhof; Stefan Kluge; Axel Linke; Ulf Landmesser; Peter Luedike; Enzo Lüsebrink; Nicolas Majunke; Norman Mangner; Octavian Maniuc; Sven Möbius-Winkler; Peter Nordbeck; Martin Orban; Federico Pappalardo; Matthias Pauschinger; Michal Pazdernik; Alastair Proudfoot; Matthew Kelham; Tienush Rassaf; Clemens Scherer; Paul Christian Sc...; Robert H. G. Schw...; Carsten Skurk; Marek Sramko; Guido Tavazzi; Holger Thiele; Luca Villanova; Nuccia Morici; Ephraim B. Winzer; Dirk Westermann; Benedikt Schrage
• Keywords: ddc:610; Original Paper; 03 medical and health sciences; 0302 clinical medicine; Medizin; 610

Abstract Background Heart failure–related cardiogenic shock (HF-CS) accounts for a significant proportion of all CS cases. Nevertheless, there is lack evidence on sex-related differences in HF-CS, especially regarding use treatment and mortality risk women vs. men. This study aimed to investigate potential clinical presentation, treatments, between men with HF-CS. Methods In this international observational study, patients HF-CS (without acute myocardial infarction) from 16 tertiary-care centers five countries were enrolled 2010 2021. Logistic Cox regression models used assess 30-day Results N = 1030 analyzed, whom 290 (28.2%) women. Compared men, more likely be older, less have known history heart failure or cardiovascular factors, lower rates highly depressed left ventricular ejection fraction renal dysfunction. severity as well treatments comparable, female sex was not independently associated (53.0% 50.8%; adjusted HR 0.94, 95% CI 0.75–1.19). Conclusions large registry, disparities factors presentation observed. Despite these differences, the both sexes exhibited similarly high rates. Further research necessary evaluate if sex-tailored treatment, accounting might improve outcomes Graphical abstract Sex-related characteristics, severity, shock. Summary main findings. AMI, infarction; CI, confidence interval; shock; LVEF, fraction; MCS, mechanical circulatory support; SCAI, Society Cardiovascular Angiography & Interventions.