Myocardial work in chronic kidney disease: insights from the CPH-CKD ECHO Study

• DOI: 10.1007/s00392-024-02459-6
• Publication Date: 2024-05-15T11:02:03Z
• Authors: Flemming Javier O...; Nino Emanuel Landler; Jacob Christensen; Bo Feldt-Rasmussen; Ditte Hansen; Christina Christo...; Ellen Linnea Free...; Ida Maria Hjelm S...; Sasha Saurbrey Bj...; Eline Seidelin; Susanne Bro; Tor Biering-Sørensen
• Keywords: Original Paper; 03 medical and health sciences; 0302 clinical medicine; Chronic nephropathy; Pressure-strain; Kidney disease; Myocardial work

Abstract Background Myocardial work is a novel echocardiographic measure that offers detailed insights into cardiac mechanics. We sought to characterize function by myocardial in patients with chronic kidney disease (CKD). Methods prospectively enrolled 757 non-dialysis-dependent CKD and 174 age- sex-matched controls. Echocardiographic pressure-strain loop analysis was performed acquire the global index (GWI). Linear regressions were investigate association between estimated glomerular filtration rate (eGFR) urine albumin-creatinine ratio (UACR) GWI. Results Patients had mean age of 57 years, 61% men, median eGFR 42 mL/min/1.73 m 2 . Overall, no difference GWI observed controls (1879 vs. 1943 mmHg%, p = 0.06). However, stepwise decline for without left ventricular hypertrophy (GWI, 1887 1789 mmHg%; trend 0.030). In CKD, not associated linear regression. diabetes modified this ( interaction 0.007), such per 10 decrease eGFR, decreased 22 (9–35) mmHg% 0.001) after multivariable adjustments diabetes, but diabetes. No UACR Conclusion exhibited lower compared matched Furthermore, decreasing only observed. Graphical