Translating novel strategies for cardioprotection: the Hatter Workshop Recommendations

• DOI: 10.1007/s00395-010-0121-4
• Publication Date: 2010-09-23T11:55:13Z
• Authors: Derek J. Hausenloy; Gary Baxter; Robert Bell; Hans Erik Bøtker; Sean M. Davidson; James Downey; Gerd Heusch; Masafumi Kitakaze; Sandrine Lecour; Robert Mentzer; Mihaela M. Mocanu; Michel Ovize; Rainer Schulz; Richard Shannon; Malcolm Walker; Gail Walkinshaw; Derek M. Yellon
• Keywords: Cardioprotection

Ischemic heart disease (IHD) is the leading cause of death worldwide. Novel cardioprotective strategies are therefore required to improve clinical outcomes in patients with IHD. Although a large number novel have been discovered research laboratory, their translation setting has largely disappointing. The reason for this failure can be attributed factors including inadequacy animal ischemia-reperfusion injury models used preclinical cardioprotection studies and inappropriate design execution studies. This important issue was main topic discussion UCL-Hatter Cardiovascular Institute 6th International Cardioprotection Workshop, outcome which published article as "Hatter Workshop Recommendations". These proposed provide guidance on both order facilitate future patient benefit.