A multistimuli-responsive supramolecular vesicle constructed by cyclodextrins and tyrosine

• DOI: 10.1007/s00396-014-3424-4
• Publication Date: 2014-12-10T07:16:44Z
• Authors: Mingfang Ma; Shengguang Xu; Pengyao Xing; Shangyang Li; Xiaoxiao Chu; Aiyou Hao
• Keywords: 01 natural sciences; 0104 chemical sciences

Stimuli-responsive vesicle is a significant self-assembly. The supramolecular amphiphile strategy provides a simple way to construct the vesicles. Here, we report a β-cyclodextrin/tyrosine supramolecular vesicle based on host-guest recognition. Tyrosine, which is a nontoxic amino acid, is used as the vesicles building blocks. The β-cyclodextrin/tyrosine vesicles were identified by transmission electron microscopy (TEM), scanning electron microscopy (SEM), and dynamic light scattering (DLS). X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), ultraviolet-visible (UV-vis) spectrum, hydrogen-1 nuclear magnetic resonance (1H NMR), and two-dimensional nuclear magnetic resonance spectroscopy rotating frame nuclear Overhauser effect spectroscopy (2D NMR ROESY) were further employed to elucidate the vesicle formation mechanism. Furthermore, different host molecules, including α-cyclodextrin and γ-cyclodextrin, can all form vesicles with tyrosine. Finally, the vesicles can respond to multiple external stimuli. Competitive guest molecules and copper ions can all disrupt the vesicles’ architectures.