Effect of hydroxypropyl cellulose and hydroxypropyl methylcellulose on carbamazepine polymorphic transformation; attenuated total reflectance-infrared spectroscopy and chemoinformatics analysis

• DOI: 10.1007/s00396-015-3698-1
• Publication Date: 2015-08-01T04:24:14Z
• Authors: Yuta Otsuka; Akira Ito; Saki Matsumura; Masaki Takeuchi; Hideji Tanaka
• Keywords: Attenuated total reflection; Hydroxypropyl cellulose

The effect of hydroxypropyl cellulose (HPC) and hydroxypropyl methylcellulose (HPMC) on carbamazepine (CBZ) polymorphic transformation has been investigated by an attenuated total reflectance-infrared (ATR-IR) spectroscopy and chemoinformatics. CBZ anhydrate samples were each kneaded with 35.0 μL of pure water, aqueous solution of 0.005 w/v% HPC, or that of 0.005 w/v% HPMC. Each paste was put on a germanium glass of an ATR accessory and was covered with a sheet of Parafilm® at 20 ± 2 °C. Measured IR spectra were analyzed by a multivariate curve resolution-alternating least squares (MCR-ALS) and a two-dimensional correlation spectroscopic analysis. Source vectors of MCR-ALS were assigned to CBZ anhydrate and dihydrate. Concentration data of MCR-ALS were evaluated for the kinetics of CBZ polymorphic transformation. The combination of ATR-IR spectroscopy and MCR-ALS is concluded to be useful for the elucidation of rapid polymorphic transformation in suspension. The transformation rate is delayed by HPC and HPMC.