The metabolic analysis of psoriasis identifies the associated metabolites while providing computational models for the monitoring of the disease

• DOI: 10.1007/s00403-017-1760-1
• Publication Date: 2017-07-10T07:55:10Z
• Authors: Aigar Ottas; Dmytro Fishman; Tiia-Linda Okas; Külli Kingo; Ursel Soomets
• Keywords: Adult; Male; 0301 basic medicine; Original Paper; 0303 health sciences; Middle Aged; 3. Good health; Young Adult; 03 medical and health sciences; Phytol; Carnitine; Alkanes; Metabolome; Phosphatidylcholines; Humans; Psoriasis; Urea; Computer Simulation; Dicarboxylic Acids; Female; Amino Acids; Aged

The majority of studies on psoriasis have focused on explaining the genetic background and its associations with the immune system's response. The aim of this study was to identify the low-molecular weight compounds contributing to the metabolomic profile of psoriasis and to provide computational models that help with the classification and monitoring of the severity of the disease. We compared the results from targeted and untargeted analyses of patients' serums with plaque psoriasis to controls. The main differences were found in the concentrations of acylcarnitines, phosphatidylcholines, amino acids, urea, phytol, and 1,11-undecanedicarboxylic acid. The data from the targeted analysis were used to build classification models for psoriasis. The results from this study provide an overview of the metabolomic serum profile of psoriasis along with promising statistical models for the monitoring of the disease.