STAT3 polymorphisms and IL-6 polymorphism are associated with the risk of basal cell carcinoma in patients from northern Poland

• DOI: 10.1007/s00403-019-01952-7
• Publication Date: 2019-07-24T11:09:50Z
• Authors: Martyna Sławińska; Monika Zabłotna; Jolanta Gleń; Joanna Lakomy; Roman J. Nowicki; Michał Sobjanek
• Keywords: Pathogenesis; Gene polymorphism

Basal cell carcinoma (BCC) environment consists of stromal and inflammatory cells which produce variety cytokines, chemokines growth factors that may affect tumor behavior. One the cytokines suggested to be involved in pathogenesis BCC is IL-6, upstream element IL-6/JAK/STAT3 pathway. The correlation between polymorphisms genes related this pathway cancer risk/prognosis have been previously investigated several neoplasia, but available data concerning are scarce. In present study, rs1800795 (-174 G/C) IL-6 gene polymorphism two STAT3 gene, namely rs2293152 (intron 11, C/G) rs4796793 (-1697, were assessed relation risk clinical course. Additionally, serum level was genotype variables. study included 254 unrelated patients with mean age 70.39 ± 11.43 (69.83 12.32 women, 71.03 10.31 men) 198 healthy, age- sex-matched volunteers. analyzed using polymerase chain reaction sequence-specific primers (SSP-PCR). Serum concentration measured ELISA test. We found presence C allele associated increased (aOR 1.86; 95% CI 1.22-2.84; p = 0.004). CC recessive model analysis 3.94; 1.59-9.77; 0.003). contrast, GC overdominant decreased 0.24; 0.12-0.49; < 0.0001). 1.31; 1.01-1.69; 0.04). GG 3.66; 1.33-10.10; 0.012). G 1.59; 1.01-2.49; positively correlated size.