Differences between psoriatic arthritis and psoriasis in multi-omics

• DOI: 10.1007/s00403-024-03018-9
• Publication Date: 2024-05-24T15:02:49Z
• Authors: Siming Gao; Hui Song
• Keywords: Proteomics; Microbiota; Arthritis, Psoriatic; Humans; Psoriasis; Metabolomics; Genomics; Transcriptome; Multiomics; Biomarkers; Epigenesis, Genetic

We aim to systemically review the genomics, transcriptomics, epigenetics, proteomics, metabonomics and microbiota of psoriatic arthritis and psoriasis, illustrating the differences of these two diseases, broadening our understanding of the pathogenesis of them and providing important clues for valuable biomarkers of earlier diagnosis and treatments. To our knowledge, this is the first study that combine all omics studies from genomics to microbiota and may serve as a reference for future studies to identify the key underlying pathways in psoriatic arthritis.