Correlation of dyslipidemia characterized by abnormal cholesterol in first trimester with early pregnancy loss: a retrospective study

• DOI: 10.1007/s00404-024-07893-5
• Publication Date: 2025-01-19T16:29:25Z
• Authors: Wei Zhang; Ruifang Wang; Xin Yang; Zhiyuan Cheng; Fang Wang
• Keywords: Dyslipidemia; Second trimester

Dyslipidemia has been linked to adverse pregnancy outcomes in observational studies. This study aimed explore how variations lipid levels during the first trimester might influence early loss (EPL). Blood samples from pregnant women were analyzed examine relationship between EPL and metabolism using logistic regression restricted cubic splines (RCS). Sensitivity analysis was conducted verify robustness of results. Elevated low-density lipoprotein cholesterol (LDL-C) total (TC) at most times 4–9 weeks gestation associated with a higher risk EPL, regardless whether control group successful or live birth. Specifically, taking as example, increased risks observed highest quartile plasma TC 4 (OR = 2.18, 95%: 1.14–4.21) 7 4.30, 1.87–9.93) pregnancy. Significant also noted third (Q3) fourth (Q4) quartiles LDL-C (Q3, OR 2.98, 1.47–6.08; Q4, 2.66, 1.27–5.55) 3.12, 1.44–6.73; 5.17, 2.14–12.49). High (> 3.25–3.78 mmol/L) high 1.92–2.04 an compared lower (≤ 2.91–3.05 1.64–1.75 mmol/L).RCS further confirmed this finding that may have linear EPL. By way, triglyceride 6 8 whereas high-density (HDL-C) 5 9 completely opposite risk. are loss, emphasizing need for monitoring even before