Efficacy of sublingual immunotherapy for house dust mite allergic rhinitis

• DOI: 10.1007/s00405-014-3444-1
• Publication Date: 2014-12-16T07:25:41Z
• Authors: Cemal Cingi; Nuray Bayar Muluk; Seçkin Ulusoy; Mustafa Acar; Seher Şirin; Bengü Çobanoğlu; Leman Birdane; Çiğdem Kalaycık; Burak Ömür Çakır; Fatih Oğhan; Sevilay Aynacı; Nagehan Erdoğmuş; Ömürsen Yıldırım; Ethem Şahin; Fuat Bulut; Mehmet Akif Aksoy; Nurullah Türe; Cengiz Bal
• Keywords: Adult; Male; Sublingual Immunotherapy; Rhinitis, Allergic, Perennial; Sublingual immunotherapy (SLIT); Pyroglyphidae; Middle Aged; Rhinitis Quality of Life Questionnaire (RQLQ); 3. Good health; Young Adult; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; House dust mite (HDM); Surveys and Questionnaires; Quality of Life; Animals; Humans; Female; Antigens, Dermatophagoides; Prospective Studies; Allergic rhinitis (AR)

In the present study, we investigated the outcomes of sublingual immunotherapy (SLIT) in house dust mite-induced allergic rhinitis (HDM-AR) patients. In this prospective, multicentric study, 186 patients with AR who had positive skin prick test results for HDMs were included. The patients were administered SLIT using Staloral 300 for 1 year. Evaluation of the patients regarding symptom scores, clinical findings and Rhinitis Quality of Life Questionnaire (RQLQ) scores was performed at baseline, and then at 6 and 12 months of therapy. Our results showed that, for all of the evaluated items (symptom scores, clinical findings and RQLQ scores), 12-month values were significantly lower than those at 6 months and baseline. Similarly, 6-month values were significantly lower than those at baseline. There were no complications in any of our patients. SLIT for HDM-AR is a treatment modality that can be used safely. We obtained better results than expected, and the treatment showed a positive psychological effect; the patients believed that SLIT was the final step of treatment and, which made them feel better.