Combined long-term enriched environment and caffeine supplementation improve memory function in C57Bl6 mice

• DOI: 10.1007/s00406-022-01431-7
• Publication Date: 2022-06-09T04:02:46Z
• Authors: Martina Stazi; Silvia Zampar; Madeleine Nadolny; Luca Büschgens; Thomas Meyer; Oliver Wirths
• Keywords: Environmental Enrichment; Memory improvement; Cognitive Decline; Barnes maze

Regular physical activity has been associated with healthy brain aging, reflected by beneficial effects on cognition and learning memory. Nutritional supplements such as caffeine have shown to act cognitive enhancers may possess neuroprotective properties. Interestingly, also improves athletic capabilities is widely used athletes because of its performance-enhancing effect, while information potential additive performance scarce. In the present study, supplementation in combination prolonged stimulation form enriched environment (EE) housing for a duration 4 months were analyzed. We demonstrate that together environmental enrichment led enhanced memory function, resulting improved recognition spatial working behavioral paradigms novel object task or Morris water maze C57Bl6 wild-type mice. Mice housed under EE conditions showed increased gene expression levels brain-derived neurotrophic factor (BDNF) hippocampus. The findings underscore impact continuous prevention age-related decline offer new options combinatorial approaches.