Pulmonary Embolism, Myocardial Infarction, and Ischemic Stroke in Lung Cancer Patients: Results from a Longitudinal Study
Risk
Male
Lung Neoplasms
POPULATION-BASED COHORT
Myocardial Infarction
03 medical and health sciences
0302 clinical medicine
Non-small cell lung cancer
Drug Therapy
Risk Factors
Humans
DEEP-VEIN THROMBOSIS
Longitudinal Studies
Registries
Pneumonectomy
Aged
Netherlands
Retrospective Studies
RISK
VENOUS THROMBOEMBOLISM
Ischemic stroke
Small cell lung cancer
Incidence
Pulmonary embolism
ADULTS
Middle Aged
3. Good health
Stroke
Myocardial infarction
HOSPITALIZATION
Case-Control Studies
Female
Pulmonary Embolism
Follow-Up Studies
DOI:
10.1007/s00408-013-9485-1
Publication Date:
2013-06-26T03:34:28Z
AUTHORS (7)
ABSTRACT
In this cohort study, the rates of pulmonary embolism (PE), myocardial infarction (MI), and ischemic stroke (IS) before and after lung cancer (LC) diagnosis were compared to cancer-free controls.Patients with LC during 2000-2007 were selected from PALGA, the Dutch Pathology Registry, and linked to the PHARMO medical record linkage system, including drug use and hospitalizations of 3 million inhabitants in the Netherlands. Included LC patients were matched 1:10 by age and gender to cancer-free controls. Hospitalizations for PE, MI, and IS were assessed in the 12 months before and after LC diagnosis.LC patients (N = 3,717) were six times more likely than cancer-free controls to have had a PE in the 12 months before diagnosis. After LC diagnosis, patients experienced an extremely increased risk of PE in the first 6 months (hazard ratio [HR] 16.8; 95 % confidence interval [CI] 7.6-36.8) compared with controls), which decreased to a five times increased risk (HR 5.1; 95 % CI 2.7-9.4) thereafter. However, there were less than two events per 100 person years during both time periods. LC patients receiving chemotherapy were eight times more likely to develop PE, whereas surgery increased the risk on PE three times. For MI and IS, no significant difference was observed compared with cancer-free controls before or after LC diagnosis.LC patients have a higher risk of developing PE compared with cancer-free controls, although the frequency of PE hospitalizations was low. Surgery and chemotherapy were associated with an increased risk of PE.
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