A Retrospective Study of Prognostic Factors in Patients with Interstitial Pneumonia Receiving Long-Term Oxygen Therapy

• DOI: 10.1007/s00408-014-9623-4
• Publication Date: 2014-07-23T16:24:28Z
• Authors: Masayoshi Higashi...; Takashi Kijima; Hiromitsu Sumikawa; Osamu Honda; Toshiyuki Minami; Haruhiko Hirata; Koji Inoue; Izumi Nagatomo; Yoshito Takeda; Hiroshi Kida; Noriyuki Tomiyama; Atsushi Kumanogoh
• Keywords: Male; 2. Zero hunger; Time Factors; Collagen Diseases; Oxygen Inhalation Therapy; Kaplan-Meier Estimate; Middle Aged; Body Mass Index; 3. Good health; 03 medical and health sciences; Sex Factors; Treatment Outcome; 0302 clinical medicine; Japan; Risk Factors; Multivariate Analysis; Humans; Female; Lung Diseases, Interstitial; Tomography, X-Ray Computed; Lung; Aged; Proportional Hazards Models; Retrospective Studies

We retrospectively analyzed patients with clinically diagnosed interstitial pneumonia to investigate the factors which contribute to the difference in prognosis from the initiation of long-term oxygen therapy (LTOT) among subtypes.Seventy-six patients with clinically diagnosed idiopathic interstitial pneumonia (IIP; n = 49) or interstitial pneumonia associated with collagen vascular disease (CVD-IP; n = 27) in whom LTOT was initiated in our facility from January 1999 to December 2012 were analyzed.Patients with CVD-IP had significantly longer survival time from the initiation of LTOT than those with IIP with the median survival of 51.7 months versus 18.8 months, respectively. The 1-year survival rate was 92.4% for patients with CVD-IP versus 76.5% for those with IIP, and 2-year survival was 88.6 versus 36.0%, respectively. The patterns classified with high-resolution computed tomography (HRCT) were not associated with prognosis. The association between pulmonary hypertension and prognosis was unclear. In results of the multivariate Cox analysis which included factors demonstrating p < 0.1 in the univariate Cox analysis, male gender, low body mass index, and the absence of collagen vascular disease (CVD) were significantly associated with poor prognosis.After the initiation of LTOT, patients with IIP had poor prognosis regardless of the patterns classified with HRCT, while those with CVD-IP survived longer. Male gender, low body mass index, and the absence of CVD were the independent negative prognostic factors in patients with interstitial pneumonia receiving LTOT.