Is Gly16Arg β2 Receptor Polymorphism Related to Impulse Oscillometry in a Real-Life Asthma Clinic Setting?

• DOI: 10.1007/s00408-016-9848-5
• Publication Date: 2016-02-15T12:27:04Z
• Authors: Sunny Jabbal; Arvind Manoharan; Joseph Lipworth; William Anderson; Philip Short; Brian Lipworth
• Keywords: Pulmonary and Respiratory Medicine; Adult; Male; Genotype; Bronchoconstriction; Beta-2 receptor; 610; Article; /dk/atira/pure/subjectarea/asjc/2700/2740; 03 medical and health sciences; 0302 clinical medicine; Gene Frequency; Adrenal Cortex Hormones; Oscillometry; Administration, Inhalation; Odds Ratio; Humans; Albuterol; Genetic Predisposition to Disease; name=Pulmonary and Respiratory Medicine; Adrenergic beta-2 Receptor Agonists; Lung; Genetic Association Studies; Impulse oscillometry; Airway Resistance; Asthma; Bronchodilator Agents; 3. Good health; Cross-Sectional Studies; Logistic Models; Female

We evaluated whether Gly16Arg beta2-receptor genotype relates to impulse oscillometry (IOS) in a real-life clinic setting.Patients with persistent asthma taking inhaled corticosteroid ± long-acting beta-agonist (ICS ± LABA) were evaluated. We compared genotype groups comprising either no Arg copies (i.e. GlyGly) versus one or two Arg copies (i.e. ArgArg or ArgGly). IOS outcomes included total airway resistance at 5 Hz (R5), central airway resistance at 20 Hz (R20), peripheral airway resistance (R5-R20), reactance at 5 Hz, area under reactance curve (AX) and resonant frequency (RF). In addition, we recorded ACQ-5 and salbutamol use.One hundred and twelve ICS-treated asthmatic patients (mean ICS dose 1238 µg/day), mean age 43 years, ACQ 2.34, FEV1 82 %, R5 177 % were identified-89 were also taking LABA. 61 patients were GlyGly, while 14 were ArgArg and 37 were ArgGly. There were no significant differences in IOS outcomes, ACQ or salbutamol use between the genotypes. The allelic risk (as odds ratio) for less well-controlled asthma (as ACQ > 1.5) was 1.1 (95 % CI 0.72-1.68) in relation to each Arg copy with a corresponding odds ratio for abnormal R5-R20 > 0.07kPA/l.s being 0.91 (95 % CI 0.57-1.44). 71 % of patients had an ACQ > 1.5 in the GlyGly group, versus 67 % in GlyArg/ArgArg group, with corresponding figures for abnormal R5-R20 > 0.07 kPa/l.s being 69 versus 73 %.In a real-life clinic setting for patients with poorly controlled persistent asthma taking ICS ± LABA, we found no evidence of any relationship of Gly16Arg to IOS, ACQ or salbutamol use.