Serum Creatinine/Cystatin C Ratio as a Predictor of In-hospital Mortality in Patients Hospitalized with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

• DOI: 10.1007/s00408-022-00568-5
• Publication Date: 2022-09-15T01:02:33Z
• Authors: Zhixiang Chen; Lei Zha; Xiao Ma; Jing Xu; Dandan Huang; Wenlong Wu; Long Chen; Feng Yang; Weiling Liao; Wenhua Wang
• Keywords: Univariate analysis

Abstract Purpose Low serum creatinine/cystatin C ratio (CCR) is associated with unfavorable characteristics in patients chronic obstructive pulmonary disease (COPD); however, the relationship between CCR and in-hospital mortality of acute exacerbation COPD (AECOPD) unexplored. Our objective was to assess value for predicting hospitalized AECOPD. Methods Patients AECOPD ( n = 597) were retrospectively enrolled. Patient’s clinical laboratory tests, including cystatin creatinine, reviewed. The prediction evaluated using area under receiver operating characteristic curve (AUC) values. Factors potentially impacting investigated univariate multivariate logistic regression analyses. Results Mortality rate during hospitalization 10.05%. lower non-surviving vs. survived (41.67 61.52, P < 0.001). AUC 0.79 [95% confidence interval (CI) 0.73–0.85]. On analysis, strongly 52.27 [odds (OR) 6.23, 95% CI (3.00–12.92), 0.001], age ≥ 81 years [OR 2.97, (1.20–7.37), 0.019], oxygenation index 300 3.28, (1.27–8.44), 0.014], CRP > 8 mg/L 1.84, (1.15–2.95), 0.012], D-dimer 500 ng/L 5.19, (1.51–17.79), 0.009]. Conclusions significantly lower, a potential prognostic indicator, who died hospitalization.