Serum Creatinine/Cystatin C Ratio as a Predictor of In-hospital Mortality in Patients Hospitalized with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

• DOI: 10.1007/s00408-022-00568-5
• Publication Date: 2022-09-15T01:02:33Z
• Authors: Zhixiang Chen; Lei Zha; Xiao Ma; Jing Xu; Dandan Huang; Wenlong Wu; Long Chen; Feng Yang; Weiling Liao; Wenhua Wang
• Keywords: Aged, 80 and over; Hospitalization; Pulmonary Disease, Chronic Obstructive; 03 medical and health sciences; 0302 clinical medicine; Creatinine; Disease Progression; COPD; Humans; Hospital Mortality; Cystatin C; Retrospective Studies; 3. Good health

Abstract Purpose

Low serum creatinine/cystatin C ratio (CCR) is associated with unfavorable characteristics in patients with chronic obstructive pulmonary disease (COPD); however, the relationship between CCR and in-hospital mortality of patients with acute exacerbation of COPD (AECOPD) is unexplored. Our objective was to assess the value of CCR for predicting in-hospital mortality of patients hospitalized with AECOPD.

Methods Patients with AECOPD (n = 597) were retrospectively enrolled. Patient’s clinical characteristics and laboratory tests, including serum cystatin C and creatinine, were reviewed. The prediction value of CCR was evaluated using area under the receiver operating characteristic curve (AUC) values. Factors potentially impacting in-hospital mortality were investigated using univariate and multivariate logistic regression analyses.

Results Mortality rate during hospitalization was 10.05%. CCR was lower in non-surviving vs. survived patients (41.67 vs. 61.52, P < 0.001). AUC value for CCR for in-hospital mortality prediction was 0.79 [95% confidence interval (CI) 0.73–0.85]. On multivariate logistic regression analysis, in-hospital mortality was strongly associated with CCR < 52.27 [odds ratio (OR) 6.23, 95% CI (3.00–12.92), P < 0.001], age ≥ 81 years [OR 2.97, 95% CI (1.20–7.37), P = 0.019], oxygenation index < 300 [OR 3.28, 95% CI (1.27–8.44), P = 0.014], CRP > 8 mg/L [OR 1.84, 95% CI (1.15–2.95), P = 0.012], and D-dimer > 500 ng/L [OR 5.19, 95% CI (1.51–17.79), P = 0.009].

Conclusions CCR was significantly lower, and is a potential prognostic indicator, in patients with AECOPD who died during hospitalization.