Influence of timing on CSF tests value for Creutzfeldt-Jakob disease diagnosis

• DOI: 10.1007/s00415-006-0472-9
• Publication Date: 2007-03-24T13:51:43Z
• Authors: P. Sanchez-Juan; R. Sánchez-Valle; A. Green; A. Ladogana; N. Cuadrado-Corrales; E. Mitrová; K. Stoeck; T. Sklaviadis; J. Kulczycki; K. Hess; A. Krasnianski; M. Equestre; D. Slivarichová; A. Saiz; M. Calero; M. Pocchiari; R. Knight; C. M. van Duijn; I. Zerr
• Keywords: Neuroradiology

The analysis of markers in the cerebrospinal fluid (CSF) is useful diagnosis sporadic Creutzfeldt-Jakob disease (sCJD). However, time at which study these most sensitive remains controversal. To assess influence sampling on value CSF tests sCJD. In framework a multinational European study, we studied results 14-3-3, S100b, neurone specific enolase (NSE) and tau protein 833 samples from sCJD patients different stages 66 sequentially repeated lumbar punctures (LP). 14-3-3 tended to increase sensitivity onset (88%, 81%) advanced stage (91%, 90%). This was significant only methionine-valine (MV) heterozygous group codon 129. absolute levels S100b (p < 0.05), NSE increased last disease. High protein, were associated with shorter survival times 0.01). Sixty-six underwent LP. These younger, had longer durations more frequently MV 129 0.001) than whole group. 64% 82% second LP = 0.025) 88% least one positive result. Sensitivity CJD progression modulated by genotype. Early negative should be inter-preted caution, especially young or those who are