Comparison of monoclonal gammopathy of undetermined significance-associated neuropathy and chronic inflammatory demyelinating polyneuropathy patients

• DOI: 10.1007/s00415-014-7357-0
• Publication Date: 2014-05-06T06:34:42Z
• Authors: Nuha M. Alkhawajah; Samantha K. Dunnigan; Vera Bril
• Keywords: Polyradiculoneuropathy; Neuroradiology; Clinical Significance

There are varying reports on whether monoclonal gammopathy of undetermined significance-associated neuropathy (MGUSN) patients distinguishable from those with chronic inflammatory demyelinating polyneuropathy (CIDP) and specific MGUSN subclasses associated clinical phenotypes.We performed a retrospective chart review (n = 56) CIDP 67) patients. Data extracted included: demographics, neurological examination, nerve conduction studies (NCS) at baseline last visit. Clinical status was rated as 0 worse, 1 unchanged, 2 stabilized after declining course, or 3 improved. The electrophysiology data were stable, Statistical analyses using JMP (version 9.0.2 for Macintosh, SAS).Seventy percent males, aged 68.1 ± 12.6 years 9.8 6.8 follow-up 4.0 3.2 years. had more severe neuropathy, likely to receive treatment respond. remained unchanged in 52.8 % the 24.2 patients, 7.6 30.3 IgM-MGUSN did not differ other immunoglobulin response treatment. severity number abnormal NCS parameters greater comparison axonal group.MGUSN have less than but among is IgM groups. may do well without exposure potential adverse effects.