Characterisation of tissue-type metabolic content in secondary progressive multiple sclerosis: a magnetic resonance spectroscopic imaging study

• DOI: 10.1007/s00415-018-8903-y
• Publication Date: 2018-05-30T04:30:06Z
• Authors: Ian Marshall; Michael J. Thripp...; Mark E. Bastin; Daisy Mollison; David A. Dickie; Francesca M. Chap...; Scott I. K. Semple; Annette Cooper; Sue Pavitt; Gavin Giovannoni; Claudia A. M. Gan...; Bhavana S. Solanky; Christopher J. Weir; Nigel Stallard; Clive Hawkins; Basil Sharrack; Jeremy Chataway; Peter Connick; Siddharthan Chandran
• Keywords: Creatine; Choline; Neuroradiology

Proton magnetic resonance spectroscopy yields metabolic information and has proved to be a useful addition structural imaging in neurological diseases. We applied short-echo time Spectroscopic Imaging cohort of 42 patients with secondary progressive multiple sclerosis (SPMS). Linear modelling respect brain tissue type yielded metabolite levels that were significantly different white matter lesions compared normal-appearing matter, suggestive higher myelin turnover (higher choline), rate creatine) increased glial activity myo-inositol) within the lesions. These findings suggest have ongoing cellular is not consistent usual assumption ‘chronic’ SPMS, may represent target for repair therapies.