Cognitive impairments are independently associated with shorter survival in diffuse glioma patients

• DOI: 10.1007/s00415-020-10303-w
• Publication Date: 2020-11-19T10:04:05Z
• Authors: Emma van Kessel; Irene M. C. Hueng...; Carla Ruis; Tatjana Seute; Susanne Fonville; Filip Y. F. L. De...; Joost J. C. Verhoeff; Pierre A. Robe; Martine J. E. van...; Tom J. Snijders
• Keywords: Cognitive skill; Executive dysfunction; Neuropsychological Assessment

Abstract Background Diffuse gliomas (WHO grade II–IV) are progressive primary brain tumors with great variability in prognosis. Cognitive deficits of important prognostic value for survival diffuse gliomas. Until now, few studies focused on domain-specific neuropsychological assessment and rather used MMSE as a measure cognitive functioning. Additionally, these did not take WHO 2016 diagnosis into account. We performed retrospective cohort study the aim to investigate independent relationship between functioning treatment-naive patients undergoing awake surgery glioma. Methods In craniotomy 2010 2017, we pre-operative assessments five domains, special attention domains executive memory. evaluated relation survival, Cox proportional hazards model that included state-of-the-art integrated histomolecular (‘layered’ or WHO-2016) classification other known factors. Results 197 patients. impairments ( Z -values ≦ − 2.0) were most frequent memory (18.3%) (25.9%). Impairments significantly correlated even after correcting possible confounders. Analyses language, psychomotor speed, visuospatial yielded no significant results. Extensive was more strongly than MMSE. Conclusion is independently related glioma Possible mechanisms underlying this include notion marker infiltration tumor option determined by overlapping genetic pathways biomarkers.